Year 2021 / Volume 28 / Supplement 1

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Article Osteoarthritis Monographic

New pharmacological targets for osteoarthritis induced pain

Rev. Soc. Esp. Dolor. 2021; 28(13): 57-63 / DOI: 10.20986/resed.2021.3863/2020

Carlos Goicoechea


ABSTRACT

Osteoarthritis can be accompanied by a painful process that is mainly independent of the pathology, since its appearance and evolution are not directly related to the progression of the disease. These differential characteristics mean that the treatment of osteoarthritis pain may require a differential approach. The growing evidence of the role of inflammation, synovitis, in this osteoarthritis related-pain has led to an increase in research aimed at identifying new drug targets. Among those that have been identified in recent years, we can highlight PGE2 (released by osteoblasts, and that can increase the expression of Nav1.8 channels), certain miRNAs and TLR receptors (activated by synovitis and which facilitate the transmission of the nociceptive signal) and nerve growth factor (NGF), which, through its binding to the trkA receptor, contributes to peripheral sensitization and chronic pain. These are just some of the most promising drug targets for osteoarthritis pain that may one day be able to remedy the pain of osteoarthritis patients.



RESUMEN

La artrosis puede provocar la aparición de un proceso doloroso que es, hasta cierto punto, independiente de la patología, dado que su aparición y evolución no están directamente relacionadas con la progresión de la enfermedad. Estas características diferenciales hacen que el tratamiento del dolor por artrosis pueda tener y requerir un abordaje particular. La evidencia creciente del papel de la inflamación, sinovitis, en este dolor ha supuesto un aumento de la investigación destinada a identificar nuevas dianas farmacológicas relacionadas con este proceso. Entre las dianas que han ido descubriéndose a lo largo de los últimos años, pueden destacarse la PGE2 (liberada por los osteoblastos, y que aumentan la expresión de canales Nav1.8), determinados miARN y receptores TLR (activados por la sinovitis y que facilitan la transmisión de la señal nociceptiva) y el factor de crecimiento nervioso (NGF), que, mediante su unión al receptor trkA, contribuye a la sensibilización periférica y a la cronificación del dolor. Estas son solo algunas de las más prometedoras dianas farmacológicas para el tratamiento del dolor asociado a la artrosis que tal vez puedan, algún día, poner remedio al dolor de los pacientes aquejados de esta enfermedad.





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Spontaneous pain is very "sympathetic"

Rev. Soc. Esp. Dolor. 2022; 29(1): 4-5 / DOI: 10.20986/resed.2022.3999/2022

Complex regional pain syndrome: the challenges and opportunities of an evolving disease

Rev. Soc. Esp. Dolor. 2022; 29(1): 1-3 / DOI: 10.20986/resed.2022.3998/2022

Commentary to the article “Fibromyalgia: possible autoimmune disease. Consideration in the inflammatory and hormonal pattern”

Rev. Soc. Esp. Dolor. 2021; 28(6): 360-360 / DOI: 10.20986/resed.2022.3949/2021

Peroneal neuropathy caused by an extraneural ganglion: literary review and treatment proposal. A non-positive case

Rev. Soc. Esp. Dolor. 2021; 28(6): 354-357 / DOI: 10.20986/resed.2022.3919/2021

Retrolaminar ultrasound guided block as analgesic treatment for post herpetic neuralgia: case report

Rev. Soc. Esp. Dolor. 2021; 28(6): 350-353 / DOI: 10.20986/resed.2022.3920/2021

Recommendations for the safe prescription of opioids in patients with a history or risk of abuse

Rev. Soc. Esp. Dolor. 2021; 28(6): 343-349 / DOI: 10.20986/resed.2022.3935/2021

Use of botulinum toxin for pain after amputation

Rev. Soc. Esp. Dolor. 2021; 28(6): 332-342 / DOI: 10.20986/resed.2022.3943/2021

Lumbar epidural steroids injections reduce catastrophism on the lumbosacral radicular syndrome

Rev. Soc. Esp. Dolor. 2021; 28(6): 325-331 / DOI: 10.20986/resed.2022.3947/2021

End-of-life transfusions in patients with an oncological diagnosis

Rev. Soc. Esp. Dolor. 2021; 28(6): 319-324 / DOI: 10.20986/resed.2022.3956/2021

Preliminary study on the evaluation of mechanical pressure pain and central pain modulation mechanisms by algometry in an anesthesia unit

Rev. Soc. Esp. Dolor. 2021; 28(6): 311-318 / DOI: 10.20986/resed.2022.3885/2021

Is pulsed radiofrequency worthwhile compared to ablative techniques in gonalgia secondary to osteoarthritis: what do we think?

Rev. Soc. Esp. Dolor. 2021; 28(6): 309-310 / DOI: 10.20986/resed.2022.3977/2022

Late onset of restless legs syndrome as a methadone withdrawal symptom in cancer patients: report of two cases

Rev. Soc. Esp. Dolor. 2021; 28(5): 298-300 / DOI: 10.20986/resed.2021.3889/2021

New opioids with different intracellular mechanism of action; is a new therapeutic window opening up?

Rev. Soc. Esp. Dolor. 2021; 28(5): 292-297 / DOI: 10.20986/resed.2021.3891/2021

A new paradigm for the treatment of knee osteoarthritis: the role of hyaluronic acid, platelet-rich plasma (PRP) and ozone in the modulation of inflammation: a review

Rev. Soc. Esp. Dolor. 2021; 28(5): 282-291 / DOI: 10.20986/resed.2021.3903/2021

Thalalgic triad. A new clinical entity from a case series

Rev. Soc. Esp. Dolor. 2021; 28(5): 276-281 / DOI: 10.20986/resed.2021.3941/2021

Efficacy and complications of analgesic techniques for the treatment of moderate to severe postoperative acute pain

Rev. Soc. Esp. Dolor. 2021; 28(5): 264-265 / DOI: 10.20986/resed.2021.3942/2021

Descriptive study on the profile of patients sent to the Chronic Pain Treatment Unit of the University Hospital of Gran Canaria Dr. Negrín (UTDC-HUGCDN) as a basis for the reorganization of this

Rev. Soc. Esp. Dolor. 2021; 28(5): 254-263 / DOI: 10.20986/resed.2021.3939/2021

Myalgic encephalitis or chronic fatigue syndrome, implications in its approach in pain units in the post-COVID era

Rev. Soc. Esp. Dolor. 2021; 28(5): 250-251 / DOI: 10.20986/resed.2021.3960/2021

Pain, emotions and locus coeruleus

Rev. Soc. Esp. Dolor. 2021; 28(5): 247-249 / DOI: 10.20986/resed.2021.3965/2021

Brachial plexus schwannoma and botulinum toxin: a case report

Rev. Soc. Esp. Dolor. 2021; 28(4): 242-245 / DOI: 10.20986/resed.2021.3924/2021

Treatment by ultrasound-guided neurolysis with 6 % aqueous phenol of the pain component for post-amputation neuromas: report of a clinical case

Rev. Soc. Esp. Dolor. 2021; 28(4): 239-241 / DOI: 10.20986/resed.2021.3928/2021

The unsolved problem of postoperative pain: critical analysis and prospects for improvement

Rev. Soc. Esp. Dolor. 2021; 28(4): 232-238 / DOI: 10.20986/resed.2021.3917/2021

Dorsal root ganlion pulsed radiofrequency for lumbosacral radicular pain: a narrative review

Rev. Soc. Esp. Dolor. 2021; 28(4): 219-231 / DOI: 10.20986/resed.2021.3882/2021

Pharmacological osteonecrosis in maxillofacial surgery, period 2013-2019

Rev. Soc. Esp. Dolor. 2021; 28(4): 211-218 / DOI: 10.20986/resed.2021.3837/2020

Clinical recommendations for rehabilitation of people with fibromyalgia. A narrative review

Rev. Soc. Esp. Dolor. 2021; 28(4): 194-210 / DOI: 10.20986/resed.2021.3932/2021

Psychological factors associated with the adherence to analgesic treatment in patients with chronic pain: systematic review of the literature

Rev. Soc. Esp. Dolor. 2021; 28(4): 181-193 / DOI: 10.20986/resed.2021.3922/2021

Comment to the article “radiofrequency intraosseous ablation of the vertebral basicervical nerve. Solution in refractory discogenic pain?”

Rev. Soc. Esp. Dolor. 2021; 28(2): 172-173 / DOI: 10.20986/resed.2021.3929/2021

Persistent hiccups after epidural injection of betamethasone: a case report

Rev. Soc. Esp. Dolor. 2021; 28(2): 169-171 / DOI: 10.20986/resed.2021.3914/2021

Genicular nerve radiofrequency in osteoarthritis-related chronic knee pain

Rev. Soc. Esp. Dolor. 2021; 28(3): 154-168 / DOI: 10.20986/resed.2021.3900/2021

Observational and prospective study on the effectiveness and safety of the dorsal root ganglion stimulation in patients with refractory neuropathic pain

Rev. Soc. Esp. Dolor. 2021; 28(2): 148-156 / DOI: 10.20986/resed.2021.3879/2020

Prescribing habits for neuropathic pain management in Spain: results of the survey of the neuropathic pain working group of the Spanish Pain Society

Rev. Soc. Esp. Dolor. 2021; 28(3): 137-147 / DOI: 10.20986/resed.2021.3911/2021

Epidemiological profile of pain secondary to moderate diabetic peripheral neuropathy

Rev. Soc. Esp. Dolor. 2021; 28(2): 129-136 / DOI: 10.20986/resed.2021.3826/2020

Results of an interdisciplinary psychoeducational intervention with EMDR in patients with fibromyalgia: a private center experience

Rev. Soc. Esp. Dolor. 2021; 28(2): 119-128 / DOI: 10.20986/resed.2021.3897/2021

Transcutaneous electrical nerve stimulation (TENS) as effective pain and fatigue management in women with fibromyalgia

Rev. Soc. Esp. Dolor. 2021; 28(2): 117-118 / DOI: 10.20986/resed.2021.3931/2021

Does it decrease the efficacy or safety of COVID-19 vaccines in patients with chronic pain?

Rev. Soc. Esp. Dolor. 2021; 28(2): 115-116 / DOI: 10.20986/resed.2021.3933/2021

Neuropathic pain: a constant challenge

Rev. Soc. Esp. Dolor. 2021; 28(2): 111-114 / DOI: 10.20986/resed.2021.3938/2021

Botulinum toxin for the treatment of myofascial pain syndrome

Rev. Soc. Esp. Dolor. 2021; 28(2): 100-110 / DOI: 10.20986/resed.2021.3902/2021

Postoperative ketamine efficacy in patients receiving chronic opioids undergoing spinal surgery

Rev. Soc. Esp. Dolor. 2021; 28(2): 92-99 / DOI: 10.20986/resed.2021.3825/2020

Risk of misuse of prescribed opioids in patients with chronic noncancer pain in a workers compensation system hospital in Chile

Rev. Soc. Esp. Dolor. 2021; 28(2): 82-91 / DOI: 10.20986/resed.2021.3845/2020

Evolution of low back pain in cancer patients treated with interventional pain management

Rev. Soc. Esp. Dolor. 2021; 28(2): 76-81 / DOI: 10.20986/resed.2021.3901/2021

Analgesic effectiveness of tapentadol in neuropathic pain secondary to post-laminectomy syndrome

Rev. Soc. Esp. Dolor. 2021; 28(2): 71-75 / DOI: 10.20986/resed.2021.3822/2020

Radiofrequency intraosseous ablation of the vertebral basicervical nerve. Solution in refractory discogenic pain?

Rev. Soc. Esp. Dolor. 2021; 28(2): 69-70 / DOI: 10.20986/resed.2021.3926/2021

Usefulness or necessity of ketamine in postoperative pain

Rev. Soc. Esp. Dolor. 2021; 28(2): 63-66 / DOI: 10.20986/resed.2021.3921/2021

Parsonage-turner after rabies vaccination due to bat bite: case report

Rev. Soc. Esp. Dolor. 2021; 28(1): 57-61 / DOI: 10.20986/resed.2021.3832/2020

Bilateral spinal erector plane block for pectus excavatum surgery in pediatric patient

Rev. Soc. Esp. Dolor. 2021; 28(1): 53-56 / DOI: 10.20986/resed.2021.3846/2020

Transfusions at the end of life. Review of some important considerations

Rev. Soc. Esp. Dolor. 2021; 28(1): 47-52 / DOI: 10.20986/resed.2021.3831/2020

Inflammatory mediators: its connection with chronic pain and associated problems. Review

Rev. Soc. Esp. Dolor. 2021; 28(1): 37-46 / DOI: 10.20986/resed.2021.3841/2020

Ozone and COVID-19: physiological bases and their therapeutic possibilities according to the evolutionary stage in SARS-CoV-2 infection

Rev. Soc. Esp. Dolor. 2021; 28(1): 27-36 / DOI: 10.20986/resed.2021.3810/2020

Management and perception of therapeutic adherence of breakthrough cancer pain by oncologists in Spain

Rev. Soc. Esp. Dolor. 2021; 28(1): 19-26 / DOI: 10.20986/resed.2021.3824/2020

Implementation and evaluation of a multimodal analgesia protocol for total knee arthroplasty including ultrasoundguided adductor canal block and periarticular local anesthetic infiltration

Rev. Soc. Esp. Dolor. 2021; 28(1): 9-18 / DOI: 10.20986/resed.2021.3847/2020

Pain related to oncologic process: old concepts and new horizons

Rev. Soc. Esp. Dolor. 2021; 28(1): 1-4 / DOI: 10.20986/resed.2021.3905/2021

Interventional management of osteoarthritic pain

Rev. Soc. Esp. Dolor. 2021; 28(13): 85-90 / DOI: 10.20986/resed.2021.3853/2020

Platelet rich plasma and intra-articular mesenchymal stem cells in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 80-84 / DOI: 10.20986/resed.2021.3858/2020

Intra-articular botulinum toxin and ozone in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 73-79 / DOI: 10.20986/resed.2021.3857/2020

Infiltrations of steroids and hyaluronic acid in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 64-72 / DOI: 10.20986/resed.2021.3854/2020

Opioids in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 49-56 / DOI: 10.20986/resed.2021.3855/2020

Review of the pharmacological treatment of osteoarthritis pain with paracetamol, non-steroid anti-inflammatory (NSAIDSS) and selective cyclooxygenase-2 inhibitors (COXIB)

Rev. Soc. Esp. Dolor. 2021; 28(13): 43-48 / DOI: 10.20986/resed.2021.3864/2020

News in the clinical practice guidelines regarding the treatment of the hip, knee and hands osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 38-42 / DOI: 10.20986/resed.2021.3870/2020

Central sensitization in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 31-37 / DOI: 10.20986/resed.2021.3876/2020

Experimental models for pain evaluation in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 18-30 / DOI: 10.20986/resed.2021.3872/2020

Ethiopathogenic mechanism of osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 11-17 / DOI: 10.20986/resed.2021.3851/2020

Epidemiology, clinical impact and therapeutic objectives in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 4-10 / DOI: 10.20986/resed.2021.3874/2020

Osteoarthritis and pain: the complexity and impact of a symptom

Rev. Soc. Esp. Dolor. 2021; 28(13): 1-3 / DOI: 10.20986/resed.2021.3886/2021

Adaptation of the chronic pain unit of the Hospital Complex from Vigo to the state of alarm due to the SARS-CoV-2 pandemic

Rev. Soc. Esp. Dolor. 2020; 27(6): 392-393 / DOI: 10.20986/resed.2020.3827/2020

Effectiveness and current recommendation of manual therapy on hip osteoarthritis. An overview

Rev. Soc. Esp. Dolor. 2020; 27(6): 375-391 / DOI: 10.20986/resed.2021.3835/2020

Transitional pain clinic

Rev. Soc. Esp. Dolor. 2020; 27(6): 369-374 / DOI: 10.20986/resed.2020.3840/2020

Study of pain in rehabilitation treatments

Rev. Soc. Esp. Dolor. 2020; 27(6): 361-368 / DOI: 10.20986/resed.2020.3809/2020

Impact of group psychological intervention on conventional radiofrequency tributary patients

Rev. Soc. Esp. Dolor. 2020; 27(6): 349-360 / DOI: 10.20986/resed.2020.3830/2020

Calcific tendinitis of the shoulder: risk factors and effectiveness of iontophoresis with acetic acid 5 % plus ultrasound: prospective quasi-experimental study at 5 years with 138 cases

Rev. Soc. Esp. Dolor. 2020; 27(6): 340-348 / DOI: 10.20986/resed.2020.3842/2020

Physical medicine, rehabilitation and pain

Rev. Soc. Esp. Dolor. 2020; 27(6): 333-335 / DOI: 10.20986/resed.2021.3888/2021

A 14-month physiotherapy follow up to a child with Sandifer syndrome

Rev. Soc. Esp. Dolor. 2020; 27(5): 329-331 / DOI: 10.20986/resed.2020.3816/2020

School of non-oncologic chronic pain patients and opioid treatment

Rev. Soc. Esp. Dolor. 2020; 27(5): 324-328 / DOI: 10.20986/resed.2020.3804/2020

Considerations for clinical examination of nonspecific neurogenic thoracic outlet syndrome

Rev. Soc. Esp. Dolor. 2020; 27(5): 316-323 / DOI: 10.20986/resed.2020.3834/2020

Opioid misuse in patients with cancer pain: an integrative systematic review of the literature

Rev. Soc. Esp. Dolor. 2020; 27(5): 306-315 / DOI: 10.20986/resed.2020.3801/2020

Therapeutic failure of the lumbar medial branch block and its relation to obesity. Retrospective cohort study

Rev. Soc. Esp. Dolor. 2020; 27(5): 298-305 / DOI: 10.20986/resed.2020.3829/2020

Identification of signs and symptoms for the diagnosis of discogenic low back pain: mapping review

Rev. Soc. Esp. Dolor. 2020; 27(5): 292-297 / DOI: 10.20986/resed.2020.3803/2020

Efficacy of lidocaine perfusions in fibromyalgia: a prospective cohort study

Rev. Soc. Esp. Dolor. 2020; 27(5): 287-291 / DOI: 10.20986/resed.2020.3796/2020

Back to the future in the treatment of postoperative acute pain

Rev. Soc. Esp. Dolor. 2020; 27(5): 285-286 / DOI: 10.20986/resed.2020.3850/2020

Temporary peripheral nerve stimulation in cancer pain: opportunity options

Rev. Soc. Esp. Dolor. 2020; 27(5): 283-284 / DOI: 10.20986/resed.2020.3849/2020

Facings with discogenic pain

Rev. Soc. Esp. Dolor. 2020; 27(5): 281-282 / DOI: 10.20986/resed.2020.3848/2020

Pain: a "hotchpotch"

Rev. Soc. Esp. Dolor. 2020; 27(4): 278-280 / DOI: 10.20986/resed.2016.3507/2016

Splanchnic nerve block for the treatment of benign chronic abdominal pain. a case report and literature review

Rev. Soc. Esp. Dolor. 2020; 27(4): 273-277 / DOI: 10.20986/resed.2020.3818/2020

Continuous analgesic control in a patient with multiple rib fractures by placing a catheter in the deep plane of the erector muscle of the spine

Rev. Soc. Esp. Dolor. 2020; 27(4): 269-272 / DOI: 10.20986/resed.2020.3800/2020

Clinical pathophysiology in patients with sickle cell disease: the transition from acute to chronic pain

Rev. Soc. Esp. Dolor. 2020; 27(4): 257-268 / DOI: 10.20986/resed.2020.3814/2020

Gender determinants in the approach to chronic pain

Rev. Soc. Esp. Dolor. 2020; 27(4): 252-256 / DOI: 10.20986/resed.2020.3802/2020

Incidence of postmastectomy pain syndrome. Retrospective analysis

Rev. Soc. Esp. Dolor. 2020; 27(4): 246-251 / DOI: 10.20986/resed.2020.3797/2020

Sociodemographic and clinical characterization in patients with chronic back pain, Cienfuegos 2019

Rev. Soc. Esp. Dolor. 2020; 27(4): 239-245 / DOI: 10.20986/resed.2020.3798/2020

Spinal cord stimulation. Analysis of the diagnostic indications

Rev. Soc. Esp. Dolor. 2020; 27(4): 234-238 / DOI: 10.20986/resed.2020.3777/2019

Updated version of the IASP definition of pain: one step forward or one step back

Rev. Soc. Esp. Dolor. 2020; 27(4): 232-233 / DOI: 10.20986/resed.2020.3839/2020

Metamizole as an immunomodulator in neuropathic pain

Rev. Soc. Esp. Dolor. 2020; 27(4): 230-231 / DOI: 10.20986/resed.2020.3838/2020

Suboccipital decompression as an alternative in the treatment of pain secundary to occipital neuralgia: a case series

Rev. Soc. Esp. Dolor. 2020; 27(3): 221-226 / DOI: 10.20986/resed.2020.3791/2020

Analgesic effect of the capsaicin 8 % patch through the TRPV-1 receptor in a case of parkinson desease with located neuropathic pain

Rev. Soc. Esp. Dolor. 2020; 27(3): 216-22 / DOI: 10.20986/resed.2020.3786/2019

Spanish Pain Society (SPS). Healthcare recommendations for pain units in the face of progressive normalization of activity during the COVID-19 pandemic

Rev. Soc. Esp. Dolor. 2020; 27(3): 192-215 / DOI: 10.20986/resed.2020.3821/2020

Symptomatic treatment for migraña. Drugs used and related variables. Results of the european survey on work and migraine

Rev. Soc. Esp. Dolor. 2020; 27(3): 178-191 / DOI: 10.20986/resed.2020.3744/2019

Characteristics of patients suffering mild to severe pain treated with orodispersible tablets of paracetamol 325 mg/tramadol HCL 37,5mg (Paxiflas®) in comparison with other oral formulations containing the same combination. PROPAX study

Rev. Soc. Esp. Dolor. 2020; 27(3): 168-177 / DOI: 10.20986/resed.2020.3771/2019

Biomechanical factors related to surgical outcomes on patients treated with lumbar arthrodesis in a high complexity center in Colombia

Rev. Soc. Esp. Dolor. 2020; 27(3): 160-167 / DOI: 10.20986/resed.2020.3759/2019

Drug consumption used for musculoskeletal pain treatment in a cohort of blue-collar workers in Zaragoza (Spain)

Rev. Soc. Esp. Dolor. 2020; 27(3): 150-159 / DOI: 10.20986/resed.2020.3749/2019

The pandemic that surprised us and has altered the care of patients with pain

Rev. Soc. Esp. Dolor. 2020; 27(3): 148-149 / DOI: 10.20986/resed.2020.3820/2020

The Pain Units in the COVID-19 era

Rev. Soc. Esp. Dolor. 2020; 27(3): 143-145 / DOI: 10.20986/resed.2020.3823/2020

Intraoperative methadone; an island among opioid free anesthesia drugs?

Rev. Soc. Esp. Dolor. 2020; 27(2): 140-142 / DOI: 10.20986/resed.2020.3789/2019

Clinical experience with the implementation of a postdural puncture headache multidisciplinary protocol

Rev. Soc. Esp. Dolor. 2020; 27(2): 133-137 / DOI: 10.20986/resed.2020.3782/2019

Erector spinalis plane block as a neuropathic pain management in post-burned pediatric patient

Rev. Soc. Esp. Dolor. 2020; 27(2): 127-132 / DOI: 10.20986/resed.2020.3776/2019

Management of breakthrough pain associated with the cure of skin ulcers

Rev. Soc. Esp. Dolor. 2020; 27(2): 113-126 / DOI: 10.20986/resed.2020.3755/2019

Efficacy of a preincisional analgesic strategy with ibuprofen, paracetamol and dexamethasone in laparoscopic cholecystectomy. Prospective observational study

Rev. Soc. Esp. Dolor. 2020; 27(2): 104-112 / DOI: 10.20986/resed.2020.3778/2019

E-consults, a new tool for pain management. Results of its implementation in an organizational structure of integrated management (EOXI)

Rev. Soc. Esp. Dolor. 2020; 27(2): 97-103 / DOI: 10.20986/resed.2020.3756/2019

Ethical problems in the management of pain. Qualitative study through open reflection interview

Rev. Soc. Esp. Dolor. 2020; 27(2): 89-96 / DOI: 10.20986/resed.2020.3729/2019

Intra-articular ozone modulates inflammation, ameliorates pain and stiffness, improves function and has anabolic effect on knee osteoarthritis: a prospective quasiexperimental before-and-after study, 115 patients

Rev. Soc. Esp. Dolor. 2020; 27(2): 78-88 / DOI: 10.20986/resed.2020.3775/2019

Altruistic conduct: a behavioral strategy to decrease the perception of pain?

Rev. Soc. Esp. Dolor. 2020; 27(2): 76-77 / DOI: 10.20986/resed.2020.3806/2020

Dimethyl fumarate: from an antipsoriatic drug to a promising antineuropathic drug

Rev. Soc. Esp. Dolor. 2020; 27(2): 74-75 / DOI: 10.20986/resed.2020.3805/2020

COVID-19 coronavirus and chronic pain: uncertainties

Rev. Soc. Esp. Dolor. 2020; 27(2): 72-73 / DOI: 10.20986/resed.2020.3808/2020

The ozone paradigm in pain treatment

Rev. Soc. Esp. Dolor. 2020; 27(2): 69-71 / DOI: 10.20986/resed.2020.3807/2020

Conventional radiofrequency for genicular nerves in treatment of knee osteoarthritis

Rev. Soc. Esp. Dolor. 2020; 27(1): 59-60 / DOI: 10.20986/resed.2016.3515/2016

Review of the impact of acupuncture treatment on the management of nonspecific low back pain

Rev. Soc. Esp. Dolor. 2020; 27(1): 53-58 / DOI: 10.20986/resed.2020.3762/2019

Effectiveness of the association of lacosamide in trigeminal neuralgia

Rev. Soc. Esp. Dolor. 2020; 27(1): 50-52 / DOI: 10.20986/resed.2019.3738/2019

Peripheral acting Mu opioid receptor antagonists in the treatment of the opioid-induced constipation: review

Rev. Soc. Esp. Dolor. 2020; 27(1): 37-49 / DOI: 10.20986/resed.2020.3717/2018

Effectiveness of patient-controlled analgesia in acute and chronic pain after cardiac surgery: a prospective study

Rev. Soc. Esp. Dolor. 2020; 27(1): 24-36 / DOI: 10.20986/resed.2020.3747/2019

Efficacy of pregabalin, gabapentin and duloxetine in neuropathic pain verified by the p-curve analysis

Rev. Soc. Esp. Dolor. 2020; 27(1): 16-23 / DOI: 10.20986/resed.2020.3727/2019

Quasi-experimental study on effectiveness of music therapy to reduce anxiety before an interventional technique in the pain unit

Rev. Soc. Esp. Dolor. 2020; 27(1): 7-15 / DOI: 10.20986/resed.2020.3767/2019

Spinal stimulation modulated automatically. Evidence of closed stimulation systems: towards the pain pacemaker

Rev. Soc. Esp. Dolor. 2020; 27(1): 5-6 / DOI: 10.20986/resed.2020.3793/2020

News in the treatment of back pain: are the future cell therapies?

Rev. Soc. Esp. Dolor. 2020; 27(1): 3-4 / DOI: 10.20986/resed.2020.3792/2020

Abducens nerve palsy associated with dural puncture and neurovascular compression

Rev. Soc. Esp. Dolor. 2019; 26(6): 376-378 / DOI: 10.20986/resed.2019.3722/2018

Considerations for the use of evidence-based practice in the management of people with pain

Rev. Soc. Esp. Dolor. 2019; 26(6): 374-375 / DOI: 10.20986/resed.2019.3712/2018

Intravenous perioperative ketamine, an old known who returns to stay?

Rev. Soc. Esp. Dolor. 2019; 26(6): 372-374 / DOI: 10.20986/resed.2019.3703/2018

Intratecal baclophene for the treatment of pain and spasticity in stiff man syndrome: a case report

Rev. Soc. Esp. Dolor. 2019; 26(6): 368-371 / DOI: 10.20986/resed.2019.3745/2019

Key factors governing spinal cord opioid bioavailability in the management of acute pain

Rev. Soc. Esp. Dolor. 2019; 26(6): 359-367 / DOI: 10.20986/resed.2019.3737/2019

Neurolytic procedures for pancreatic cáncer pain: a systematic review and a proposal for an algorithm treatment

Rev. Soc. Esp. Dolor. 2019; 26(6): 342-358 / DOI: 10.20986/resed.2019.3715/2018

Valuation of the relationship between the rotational restriction of high cervical column and high thoracic column in students with and without cervical pain of the Faculty of Sciences of the Rehabilitation

Rev. Soc. Esp. Dolor. 2019; 26(6): 337-341 / DOI: 10.20986/resed.2019.3698/2018

Correlation study between diagnostic opportunity and pain severity in patients with fibromyalgia who enter the Nononcological Chronic Pain Unit at the San Borja Arriarán Clinical Hospital

Rev. Soc. Esp. Dolor. 2019; 26(6): 331-336 / DOI: 10.20986/resed.2019.3690/2018

Correlation between pain and radiological parameters in patients older than 60 years of age with distal radius fracture

Rev. Soc. Esp. Dolor. 2019; 26(6): 324-330 / DOI: 10.20986/resed.2019.3720/2018

Connexins in chronic pain. A new target?

Rev. Soc. Esp. Dolor. 2019; 26(6): 322-323 / DOI: 10.20986/resed.2019.3785/2019

Celiac axis block in cancer pain: medicine of opportunity

Rev. Soc. Esp. Dolor. 2019; 26(6): 317-319 / DOI: 10.20986/resed.2019.3787/2019

Pyoderma gangrenosum, undocumented complication of a spinal cord stimulation

Rev. Soc. Esp. Dolor. 2019; 26(5): 309-312 / DOI: 10.20986/resed.2019.3725/2019

Cervical epidural anesthesia and analgesia for upper limb surgery

Rev. Soc. Esp. Dolor. 2019; 26(5): 304-308 / DOI: 10.20986/resed.2019.3686/2018

Applicability of scales/indicators for pain monitoring in critically ill patients incapable of verbalizing: a systematic review of the literature

Rev. Soc. Esp. Dolor. 2019; 26(5): 293-303 / DOI: 10.20986/resed.2019.3726/2019

The medical doctors who perform their care and research work in pain units in the use of the internet: identification, characterization and determinants

Rev. Soc. Esp. Dolor. 2019; 26(5): 284-292 / DOI: 10.20986/resed.2019.3713/2018

Validation of the coping strategies to chronic pain reduced questionnaire in the cienfuegan population with chronic back pain (2017-2018)

Rev. Soc. Esp. Dolor. 2019; 26(5): 276-283 / DOI: 10.20986/resed.2019.3732/2019

New strategies for postoperative pain control in tonsillectomy surgery. Is all that glitters gold?

Rev. Soc. Esp. Dolor. 2019; 26(5): 270-275 / DOI: 10.20986/resed.2019.3742/2019

Epidural betamethasone injection in lumbosacral radicular syndrome: effi cacy evaluation for interlaminar and transforaminal approaches

Rev. Soc. Esp. Dolor. 2019; 26(5): 263-269 / DOI: 10.20986/resed.2019.3700/2018

The use of new technologies in patients with chronic pain. A reality that cannot be denied

Rev. Soc. Esp. Dolor. 2019; 26(5): 259-260 / DOI: 10.20986/resed.2019.3766/2019

Epidural injections: caudal, interlaminar or transforaminal. More than a shot

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Characterization of pain in patients with breast cancer attending the Oncology Unit of the San José Hospital

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Nerve distribution in human temporomandibular articular disc using Sihler staining technique: a cadaveric descriptive approach

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Proctalgia and pudendal nerve entrapment: an association to know

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Radiofrequency thermal and splanchnics nerves block

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Implications of bioethics in the treatment of chronic pain: the change of paradigms

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Farmacologic adyuvants with saving effect of opioids in the perioperative period

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Experience in two hospitals about the observation of pain responses in hospitalized preterm infants

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Platelet-rich plasma in treating peripheral neuropathic pain. Preliminary report

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Pain in the elderly and in patients with cognitive deficit. A DELPHI study

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Trial therapy on laterality and motor imagery and selective glenohumeral muscle activation in patients with massive rotator cuff tear: case series

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Expenditure, prescription and consumption of analgesic drugs before and during the economic crisis

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Sex and pain: sexual satisfaction and sexual function in a sample of patients with chronic, non-pelvic pain

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Bibliometric analysis of the Journal of the Spanish Pain Society: 2007-2016

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Analgesic efficacy of topical sevoflurane on wounds

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Pharmacological management of acute postoperative pain in Spain. Data from the national survey by the Spanish Pain Society (SED)

Rev Soc Esp Dolor 2018; 25(2): 70-85 / DOI: 10.20986/resed.2017.3593/2017

Potential uses of Mirtazapine in palliative care beyond its antidepressant effect

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Prevalence of pain in patients hospitalized in Metabolic Intensive Care Units with orotracheal intubation and under sedation, measured with the COMFORT scale

Rev Soc Esp Dolor 2018; 25(1): 7-12 / DOI: 10.20986/resed.2017.3581/2017

Pain management in cancer patients receiving radiotherapy: GORVAMUR study, a prospective, observational, epidemiological study

Rev Soc Esp Dolor 2017; 24(5): 241-255 / DOI: 10.20986/resed.2017.3570/2017

Epidural analgesia vs. surgical wound analgesia to control acute post-operative pain in open colon surgery

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CAD-R. Chronic pain coping questionnaire: confirmatory factor analysis. Are there individual differences in gender, age and type of pain?

Rev Soc Esp Dolor 2017; 24(5): 224-233 / DOI: 10.20986/resed.2017.3558/2016

Intervention of manual motor skill exercises on pain and functionality in adults subjects with rheumatoid arthritis: case series

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Characterization of chest pain in patients attending the emergency department of a high-complexity-level healthcare institution, during 2014-2015, in Medellín, Colombia

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Chronic pain: relationship with prefrontal symptoms and perceived stress

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The effectiveness of electrical spinal-cord stimulation in type i complex regional pain syndrome. A literature review

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Paxiflas®: new FDT combination of tramadol/paracetamol for treating moderate to severe pain

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The predictive role of rumination and trait mindfulness in pain and negative mood after a sport injury: a longitudinal study

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Prevalence of breakthrough pain associated with chronic low back pain in Andalusia (COLUMBUS study)

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Effectiveness of hyaluronic acid intra-articular injections in treating knee osteoarthritis: results of a series of cases treated in a Pain Unit

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Prescribing strong opioids in patients with non-cancer pain: a description of their characteristics in an area of primary healthcare assistance

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Factors associated with pain intensity in Mexican patients hospitalized in postoperative period

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Instrucciones para citar

Goicoechea C. New pharmacological targets for osteoarthritis induced pain. Rev Soc Esp Dolor 2021; 28(13): 57-63 / DOI: 1020986/resed20213863/2020


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Aceptado: 18/01/2021

Publicado: 03/02/2021


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