Year 2020 / Volume 27 / Number 2

Original

Intra-articular ozone modulates inflammation, ameliorates pain and stiffness, improves function and has anabolic effect on knee osteoarthritis: a prospective quasiexperimental before-and-after study, 115 patients

Rev. Soc. Esp. Dolor. 2020; 27(2): 78-88 / DOI: 10.20986/resed.2020.3775/2019

Marcos Edgar Fernández-Cuadros, Olga Susana Pérez-Moro, María Jesús Albaladejo-Florin, Sandra Álava


ABSTRACT

Purpose: The objective of the present study is to verify for the first time in the literature the symptomatic and modifying disease effect of ozone (O2-O3) through clinical (pain, function and stiffness), biochemical (C-reactive protein [CRP], erythrocyte sedimentation rate [ESR], uric acid) and radiological improvement (minimum medial and lateral joint space) in a series of patients with osteoarthritis of the knee.
Methods: A prospective quasi-experimental beforeand-after study was performed in 115 patients with knee osteoarthritis Kellgren-Lawrence grade 2 or more. The ozone protocol consisted of 4 sessions (one session / week) of an intra-articular injection of 20 ml of a medical mixture of Oxygen-Ozone (95-5ºC) at a concentration of 20 μg / ml. Outcome variables included clinical (pain, stiffness, and function), biochemical (CRP, ESR, uric acid), and radiological variables (minimal femorotibial joint space).
Results: Mean age of the patients was 64.81 ± 11.22 years. Female patients accounted for 75.6 % (n = 87), with a female / male ratio of 3 : 1. Biochemical-variables: CRP decreased from 0.42 ± 0.54 mg/dL to 0.31 ± 0.33 mg/dL (p = 0.0142). ESR decreased from 14.52 ± 10.14 mm/h to 13.08 ± 8.78 mm/h (p= 0.0014). Serum uric acid decreased from 5.12 ± 1.22 mg/dL to 5.05 ± 1.24 (p = 0.1307).
Clinical variables: Ozone (O2-O3) significantly improved pain, stiffness and function clinical variables (p = 0.0000). Pain measured by VAS was 7.11 ± 1.11 points and decreased significantly to 3.56 ± 1.56 points (p = 0.0000). Before the intervention, WOMAC-pain subscale was 14.3 ± 22.29 points and decreased to 7.13 ± 33.13 points (p = 0.0000), WOMAC-stiffness subscale was 2.73 ± 1.39 points and decreased to 1.16 ± 1.13 points (p = 0.0000), WOMAC-function subscale was 41.66 ± 8, 1 points and improved to 25.29 ± 9.72 points (p = 0.0000).
Radiological variables: In 53 patients analyzed radiologically (according to standardized protocol) at one year of follow-up after ozone treatment, the internal compartment increased significantly from 4.12 ± 1.41 mm to 4.4 ± 1.35 mm (p = 0.0008) and the external compartment increased from 6 ± 1.37 to 6.16 ± 1.4 mm (p = 0.0753).
Conclusions: Intra articular ozone has demonstrated a symptomatic and disease modifying effect in patients with osteoarthritis of the knee, improving pain, function and stiffness; decreasing markers of inflammation (CRP, ESR and uric acid), and increasing the minimal joint space of the medial and lateral component evidenced radiologically. In this study it has been shown that ozone modulates inflammation, decreases pain and stiffness, improves function and has an anabolic effect in patients with osteoarthritis of the knee. No adverse effect has been observed after intra articular infiltrations of ozone.



RESUMEN

Objetivo: El objetivo del presente estudio es verificar por primera vez en la literatura el efecto sintomático y modificador de enfermedad del ozono (O2-O3) mediante la mejoría clínica (dolor, función y rigidez), bioquímica (proteína C-reactiva [PCR], velocidad de sedimentación globular [VSG], ácido úrico) y radiológica (mínimo espacio articular medial y lateral) en una serie de pacientes con artrosis de rodilla.
Material y métodos: Se realizó un estudio cuasiexperimental prospectivo tipo antes y después a 115 pacientes con artrosis de rodilla con Kellgren-Lawrence grado 2 o más. El protocolo de ozono consistió en 4 sesiones (una sesión/semana) de una infiltración intrarticular de 20 ml de una mezcla médica de oxígeno-ozono (95-5 %) a una concentración de 20 μg/ml. Las variables de resultado incluyeron variables clínicas (dolor, rigidez y función), bioquímicas (PCR, VSG, ácido úrico) y radiológicas (mínimo espacio articular femorotibial).
Resultados: La edad media de los pacientes fue de 64.81 ± 11.22 años. Los pacientes femeninos representaron el 75.6 % (n = 87), con una relación mujer/hombre de 3:1.
Variables bioquímicas: la PCR disminuyó de 0.42 ± 0.54 mg/dl a 0.31 ± 0.33 mg/dl (p = 0.0142). La VSG disminuyó sus valores desde 14.52 ± 10.14 mm/h hasta 13.08 ± 8.78 mm/h (p = 0,0014). El ácido úrico en suero disminuyó su valor de 5.12 ± 1.22 mg/dl a 5.05 ± 1.24 (p = 0.1307).
Variables clínicas: el ozono (O2-O3) mejoró significativamente las variables clínicas dolor, rigidez y función (p = 0.0000). El dolor medido por EVA fue de 7.11 ± 1.11 puntos y disminuyó significativamente a 3.56 ± 1.56 puntos (p = 0.0000). Antes de la intervención, la subescala WOMAC-dolor fue de 14.3 ± 2.29 puntos y disminuyó a 7.13 ± 3.13 puntos (p = 0.0000), la subescala WOMAC-rigidez fue de 2.73 ± 1.39 puntos y disminuyó a 1.16 ± 1.13 puntos (p = 0.0000), la subescala WOMAC-función fue de 41.66 ± 8.1 puntos y mejoró a 25.29 ± 9.72 puntos (p = 0.0000).
Variables radiológicas: en 53 pacientes analizados radiológicamente (según protocolo estandarizado) al año de seguimiento después del tratamiento con ozono, el compartimento interno aumento significativamente de 4.12 ± 1.41 mm a 4.4 ± 1.35 mm (p = 0.0008) y el compartimento externo aumentó de 6 ± 1.37 a 6.16 ± 1.4 mm (p = 0.0753).
Conclusiones: El ozono intrarticular ha demostrado efecto sintomático y modificador de la enfermedad en los pacientes con artrosis de rodilla, mejorando el dolor, la función y la rigidez; disminuyendo los marcadores de inflamación (PCR, VSG y ácido úrico), y aumentando el mínimo espacio articular del componente medial y lateral evidenciado radiológicamente. En este estudio se ha evidenciado que el ozono modula la inflamación, disminuye el dolor y la rigidez, mejora la función y tiene efecto anabólico en los pacientes con artrosis de rodilla. No se ha observado ningún efecto adverso tras las infiltraciones intrarticulares de ozono.





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Bibliografía

1. Fernández-Cuadros ME, Pérez-Moro OS, Albaladejo-Florín MJ. Ozone fundamentals and effectiveness in knee pain: Chondromalacia and knee osteoarthritis. Germany: Lambert Academic Publishing; 2016.
2. Fernández-Cuadros ME. Análisis de la calidad de vida en pacientes con prótesis de rodilla. Tesis doctoral. Universidad de Salamanca. España. 2013.
3. Raynauld JP, Pelletier JP, Abram F, Dodin P, Delorme P, Martel‐Pelletier J. Long‐term effects of glucosamine and chondroitin sulfate on the progression of structural changes in knee osteoarthritis: six‐year follow-up data from the Osteoarthritis Initiative. Arthritis Care Res (Hobboken). 2016;68(10):1560-6. DOI: 10.1002/acr.22866.
4. Fernández‐Cuadros ME. Does glucosamine/chondroitin sulfate have a long‐term effect on the progression of structural changes in knee osteoarthritis? Comment on the article by Raynauld et al. Arthritis Care Res (Hobboken). 2018;70(1):167. DOI: 10.1002/acr.23313.
5. Fernández-Cuadros ME, Perez-Moro OS, Miron-Canelo JA. Could ozone be used as a feasible future treatment in osteoarthritis of the knee. Diversity Equal Health Care. 2016;13(3):232-9.
6. Fernandez-Cuadros ME, Perez-Moro OS, Albaladejo-Florin MJ, Algarra-Lopez R. Ozone decreases biomarkers of inflammation (C-reactive protein and erytrocyte sedimentation rate) and improves pain, function and quality of life in knee osteoarthritis patients: a before-and-after study and review of the literature. Middle East J Rehabil Health Stud. 2018; 5(2):e64507. DOI: 10.5812/mejrh.64507.
7. Fernández-Cuadros ME, Pérez-Moro OS, Albaladejo-Florín MJ, Algarra-Lopez R. Intra articular ozone reduces serum uric acid and improves pain, function and quality of life in knee osteoarthritis patients: a before-and-after study. Middle East J Rehabil Health Stud. 2018;5(3):e68599. DOI: 10.5812/mejrh.68599.
8. Fernández-Cuadros ME, Pérez-Moro OS, Albaladejo-Florín M, Mirón-Canelo JA. Ozone improves pain, function and quality of life in patients with knee osteoarthritis: A prospective quasi-experimental before-after study. Middle East J Rehabil Health Stud. 2017;4(1):e41821. DOI: 10.17795/mejrh-41821.
9. Fernández-Cuadros ME, Pérez-Moro OS, Albaladejo-Florín MJ. Knee osteoarthritis: Condroprotector action and symptomatic effect of ozone on pain, function, quality of life, minimal joint space and knee arthroplasty delay. Middle East J Rehabil Health Stud. 2017;4(1):e43200. DOI: 10.17795/mejrh-43200.
10. Buckland-Wright JC, Macfarlane DG, Williams SA, Ward RJ. Accuracy and precision of joint space width measurements in standard and macroradiographs of osteoarthritic knees. Ann Rheum Dis, 1995;54(11):872-80. DOI: 10.1136/ard.54.11.872.
11. Pérez-Moro O, Albaladejo-Florín M, Entrambasaguas-Estepa B, Fernández-Cuadros, M. Effectivenness of PRP on pain, function and quality of life in chondromalacia and patellofemoral pain syndrome: A pretest-postest analysis. Nov Tech Arthritis Bone Res. 2017;1(1):1-8.
12. Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW. Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol. 1988;15(12):1833-40.
13. Malathi R, Kothari S, Chattopadhyay A, Agrawal PK, Banerjee U, Sahu RK. Raised serum IL 6 and CRP in radiographic knee osteoarthritis in Eastern India. JMSR. 2017;5(5):21687-92. DOI: 10.18535/jmscr/v5i5.73.
14. Ayral X, Pickering EH, Woodworth TG, Mackillop N, Dougados M. Synovitis: a potential predictive factor of structural progression of medial tibiofemoral knee osteoarthritis–results of a 1 year longitudinal arthroscopic study in 422 patients. Osteoarthritis Cartilage. 2005;13(5):361-7. DOI: 10.1016/j.joca.2005.01.005.
15. Smith JW, Martins TB, Gopez E, Johnson T, Hill HR, Rosenberg T D. Significance of C-reactive protein in osteoarthritis and total knee arthroplasty outcomes. Ther Adv Musculoskelet Dis. 2012;4(5):315-25. DOI: 10.1177/1759720X12455959.
16. Lotz M, Martel-Pelletier J, Christiansen C, Brandi ML, Bruyère O, Chapurlat R, et al. Value of biomarkers in osteoarthritis: current status and perspectives. Ann Rheum Dis. 2013;72(11):1756-63. DOI: 10.1136/annrheumdis-2013-203726.
17. Spector TD, Hart DJ, Nandra D, Doyle DV, Mackillop N, Gallimore JR, Pepys MB. Low‐level increases in serum C‐reactive protein are present in early osteoarthritis of the knee and predict progressive disease. Arthritis Rheum. 1997;40(4):723-7. DOI: 10.1002/art.1780400419.
18. Arendt‐Nielsen L, Eskehave TN, Egsgaard LL, Petersen KK, Graven‐Nielsen T, Hoeck HC, et al. Association between experimental pain biomarkers and serologic markers in patients with different degrees of painful knee osteoarthritis. Arthritis Rheumatol, 2014;66(12):3317-26. DOI: 10.1002/art.38856.
19. Sanchez-Ramirez DC, van der Leeden M, van der Esch M, Gerritsen M, Roorda LD, Verschueren S, et al. Association of serum C-reactive protein and erythrocyte sedimentation rate with muscle strength in patients with knee osteoarthritis. Rheumatology (Oxford). 2012;52(4):727-32. DOI: 10.1093/rheumatology/kes366.
20. Zhu Z, Jin X, Wang B, Wluka A, Antony B, Laslett L, et al. Cross-sectional and longitudinal associations between serum levels of high-sensitivity C-reactive protein, bone marrow lesions, and knee pain in patients with knee osteoarthritis. Arthritis Care Res (Hoboken). 2016;68(10):1471-77. DOI: 10.1002/acr.22834.
21. Roddy E, Doherty M. Gout and osteoarthritis: a pathogenetic link? Joint Bone Spine. 2012;79(5):425-7. DOI: 10.1016/j.jbspin.2012.03.013.
22. Ma CA, Leung YY. Exploring the link between uric acid and osteoarthritis. Front Med (Lausanne). 2017;4:225. DOI: 10.3389/fmed.2017.00225.
23. Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J. Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature. 2006;440(7081):237. DOI: 10.1038/nature04516.
24. Denoble AE, Huffman KM, Stabler TV, Kelly SJ, Hershfield MS, McDaniel GE, et al. Uric acid is a danger signal of increasing risk for osteoarthritis through inflammasome activation. Proc Natl Acad Sci U S A. 2011;108(5):2088-93. DOI: 10.1073/pnas.1012743108.
25. Bonora E, Targher G, Zenere MB, Saggiani F, Cacciatori V, Tosi F, et al. Relationship of uric acid concentration to cardiovascular risk factors in young men. Role of obesity and central fat distribution. The Verona Young Men Atherosclerosis Risk Factors Study. Int J Obes Relat Metab Disord. 1996;20(11):975-80.
26. Lyngdoh T, Marques-Vidal P, Paccaud F, Preisig M, Waeber G, Bochud M,et al. Elevated serum uric acid is associated with high circulating inflammatory cytokines in the population-based Colaus study. PLoS One. 2011;6(5):e19901. DOI: 10.1371/journal.pone.0019901.
27. Wangkaew S, Kasitanon N, Hongsongkiat S, Tanasombat C, Sukittawut W, Louthrenoo W, et al. A comparative study of serum and synovial fluid levels of uric acid between patients with gout and other arthritides. J Med Assoc Thai. 2014;97(7):679-85.
28. Billiet L, Doaty S, Katz JD, Velasquez MT. Review of hyperuricemia as new marker for metabolic syndrome. ISRN Rheumatol. 2014;2014:852954. DOI: 10.1155/2014/852954.
29. Cho HJ, Chang CB, Yoo JH, Kim SJ, Kim TK. Gender differences in the correlation between symptom and radiographic severity in patients with knee osteoarthritis. Clin Orthop Relat Res. 2010;468(7):1749-58. DOI: 10.1007/s11999-010-1282-z.
30. Neumann G, Hunter D, Nevitt M, Chibnik LB, Kwoh K, Chen H, et al. Location specific radiographic joint space width for osteoarthritis progression. Osteoarthritis Cartilage. 2009;17(6):761-5. DOI: 10.1016/j.joca.2008.11.001.
31. Mazzuca SA, Brandt KD, Katz BP. Is conventional radiography suitable for evaluation of a disease-modifying drug in patients with knee osteoarthritis? Osteoarthritis Cartilage. 1997;5(4):217-26. DOI: 10.1016/S1063-4584(97)80017-9.
32. Altman RD, Fries JF, Bloch DA, Carstens J, Cooke TD, Genant H, et al. Radiographic assessment of progression in osteoarthritis. Arthritis Rheum. 1987;30(11):1214-25. DOI: 10.1002/art.1780301103.
33. Conrozier T, Favret H, Mathieu P, Piperno M, Provvedini D, Taccoen A, et al. Influence of the quality of tibial plateau alignment on the reproducibility of computer joint space measurement from Lyon schuss radiographic views of the knee in patients with knee osteoarthritis. Osteoarthritis Cartilage. 2004;12(10):765-70. DOI: 10.1016/j.joca.2004.06.003.
34. Altman R, Brandt K, Hochberg M, Moskowitz R, Bellamy N, Bloch DA,.et al. Design and conduct of clinical trials in patients with osteoarthritis: recommendations from a task force of the Osteoarthritis Research Society: results from a workshop. Osteoarthritis Cartilage. 1996;4(4):217-43. DOI: 10.1016/S1063-4584(05)80101-3.
35. Cicuttini F, Hankin J, Jones G, Wluka A. Comparison of conventional standing knee radiographs and magnetic resonance imaging in assessing progression of tibiofemoral joint osteoarthritis. Osteoarthritis Cartilage. 2005;13(8):722-7. DOI: 10.1016/j.joca.2005.04.009.
36. Cicuttini F, Hankin J, Jones G, Wluka A. Comparison of conventional standing knee radiographs and magnetic resonance imaging in assessing progression of tibiofemoral joint osteoarthritis. Osteoarthritis Cartilage. 2005;13(8):722-7. DOI: 10.1016/j.joca.2005.04.009.
37. Noori-Zadeh A, Bakhtiyari S, Khooz R, Haghani K, Darabi S. Intra-articular ozone therapy efficiently attenuates pain in knee osteoarthritic subjects: A systematic review and meta-analysis. Complement Ther Med. 2019;42:240-7. DOI: 10.1016/j.ctim.2018.11.023.
38. Arias-Vázquez PI, Tovilla-Zárate CA, Bermudez-Ocaña DY, Legorreta-Ramírez BG, López-Narváez ML. Eficacia de las infiltraciones con ozono en el tratamiento de la osteoartritis de rodilla vs. otros tratamientos intervencionistas: revisión sistemática de ensayos clínicos. Rehabilitación. 2019;53(1):43-55. DOI: 10.1016/j.rh.2018.11.001.
39. Sconza C, Respizzi S, Virelli L, Vandenbulcke F, Iacono F, Kon E, et al. Oxygen–ozone therapy for the treatment of knee osteoarthritis: a systematic review of randomized controlled trials. Arthroscopy. 2020;36(1):277-86.
40. Oliviero A, Giordano L, Maffulli N. The temporal effect of intra-articular ozone injections on pain in knee osteoarthritis. Br Med Bull. 2019;132(1):33-44. DOI: 10.1093/bmb/ldz028.

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Thalalgic triad. A new clinical entity from a case series

Rev. Soc. Esp. Dolor. 2021; 28(5): 276-281 / DOI: 10.20986/resed.2021.3941/2021

Efficacy and complications of analgesic techniques for the treatment of moderate to severe postoperative acute pain

Rev. Soc. Esp. Dolor. 2021; 28(5): 264-265 / DOI: 10.20986/resed.2021.3942/2021

Myalgic encephalitis or chronic fatigue syndrome, implications in its approach in pain units in the post-COVID era

Rev. Soc. Esp. Dolor. 2021; 28(5): 250-251 / DOI: 10.20986/resed.2021.3960/2021

Pain, emotions and locus coeruleus

Rev. Soc. Esp. Dolor. 2021; 28(5): 247-249 / DOI: 10.20986/resed.2021.3965/2021

The unsolved problem of postoperative pain: critical analysis and prospects for improvement

Rev. Soc. Esp. Dolor. 2021; 28(4): 232-238 / DOI: 10.20986/resed.2021.3917/2021

Dorsal root ganlion pulsed radiofrequency for lumbosacral radicular pain: a narrative review

Rev. Soc. Esp. Dolor. 2021; 28(4): 219-231 / DOI: 10.20986/resed.2021.3882/2021

Clinical recommendations for rehabilitation of people with fibromyalgia. A narrative review

Rev. Soc. Esp. Dolor. 2021; 28(4): 194-210 / DOI: 10.20986/resed.2021.3932/2021

Persistent hiccups after epidural injection of betamethasone: a case report

Rev. Soc. Esp. Dolor. 2021; 28(2): 169-171 / DOI: 10.20986/resed.2021.3914/2021

Genicular nerve radiofrequency in osteoarthritis-related chronic knee pain

Rev. Soc. Esp. Dolor. 2021; 28(3): 154-168 / DOI: 10.20986/resed.2021.3900/2021

Epidemiological profile of pain secondary to moderate diabetic peripheral neuropathy

Rev. Soc. Esp. Dolor. 2021; 28(2): 129-136 / DOI: 10.20986/resed.2021.3826/2020

Transcutaneous electrical nerve stimulation (TENS) as effective pain and fatigue management in women with fibromyalgia

Rev. Soc. Esp. Dolor. 2021; 28(2): 117-118 / DOI: 10.20986/resed.2021.3931/2021

Does it decrease the efficacy or safety of COVID-19 vaccines in patients with chronic pain?

Rev. Soc. Esp. Dolor. 2021; 28(2): 115-116 / DOI: 10.20986/resed.2021.3933/2021

Neuropathic pain: a constant challenge

Rev. Soc. Esp. Dolor. 2021; 28(2): 111-114 / DOI: 10.20986/resed.2021.3938/2021

Botulinum toxin for the treatment of myofascial pain syndrome

Rev. Soc. Esp. Dolor. 2021; 28(2): 100-110 / DOI: 10.20986/resed.2021.3902/2021

Postoperative ketamine efficacy in patients receiving chronic opioids undergoing spinal surgery

Rev. Soc. Esp. Dolor. 2021; 28(2): 92-99 / DOI: 10.20986/resed.2021.3825/2020

Evolution of low back pain in cancer patients treated with interventional pain management

Rev. Soc. Esp. Dolor. 2021; 28(2): 76-81 / DOI: 10.20986/resed.2021.3901/2021

Analgesic effectiveness of tapentadol in neuropathic pain secondary to post-laminectomy syndrome

Rev. Soc. Esp. Dolor. 2021; 28(2): 71-75 / DOI: 10.20986/resed.2021.3822/2020

Radiofrequency intraosseous ablation of the vertebral basicervical nerve. Solution in refractory discogenic pain?

Rev. Soc. Esp. Dolor. 2021; 28(2): 69-70 / DOI: 10.20986/resed.2021.3926/2021

Usefulness or necessity of ketamine in postoperative pain

Rev. Soc. Esp. Dolor. 2021; 28(2): 63-66 / DOI: 10.20986/resed.2021.3921/2021

Parsonage-turner after rabies vaccination due to bat bite: case report

Rev. Soc. Esp. Dolor. 2021; 28(1): 57-61 / DOI: 10.20986/resed.2021.3832/2020

Bilateral spinal erector plane block for pectus excavatum surgery in pediatric patient

Rev. Soc. Esp. Dolor. 2021; 28(1): 53-56 / DOI: 10.20986/resed.2021.3846/2020

Inflammatory mediators: its connection with chronic pain and associated problems. Review

Rev. Soc. Esp. Dolor. 2021; 28(1): 37-46 / DOI: 10.20986/resed.2021.3841/2020

Management and perception of therapeutic adherence of breakthrough cancer pain by oncologists in Spain

Rev. Soc. Esp. Dolor. 2021; 28(1): 19-26 / DOI: 10.20986/resed.2021.3824/2020

Pain related to oncologic process: old concepts and new horizons

Rev. Soc. Esp. Dolor. 2021; 28(1): 1-4 / DOI: 10.20986/resed.2021.3905/2021

Interventional management of osteoarthritic pain

Rev. Soc. Esp. Dolor. 2021; 28(13): 85-90 / DOI: 10.20986/resed.2021.3853/2020

Platelet rich plasma and intra-articular mesenchymal stem cells in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 80-84 / DOI: 10.20986/resed.2021.3858/2020

Intra-articular botulinum toxin and ozone in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 73-79 / DOI: 10.20986/resed.2021.3857/2020

Infiltrations of steroids and hyaluronic acid in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 64-72 / DOI: 10.20986/resed.2021.3854/2020

New pharmacological targets for osteoarthritis induced pain

Rev. Soc. Esp. Dolor. 2021; 28(13): 57-63 / DOI: 10.20986/resed.2021.3863/2020

Opioids in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 49-56 / DOI: 10.20986/resed.2021.3855/2020

News in the clinical practice guidelines regarding the treatment of the hip, knee and hands osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 38-42 / DOI: 10.20986/resed.2021.3870/2020

Central sensitization in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 31-37 / DOI: 10.20986/resed.2021.3876/2020

Experimental models for pain evaluation in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 18-30 / DOI: 10.20986/resed.2021.3872/2020

Ethiopathogenic mechanism of osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 11-17 / DOI: 10.20986/resed.2021.3851/2020

Epidemiology, clinical impact and therapeutic objectives in osteoarthritis

Rev. Soc. Esp. Dolor. 2021; 28(13): 4-10 / DOI: 10.20986/resed.2021.3874/2020

Osteoarthritis and pain: the complexity and impact of a symptom

Rev. Soc. Esp. Dolor. 2021; 28(13): 1-3 / DOI: 10.20986/resed.2021.3886/2021

Adaptation of the chronic pain unit of the Hospital Complex from Vigo to the state of alarm due to the SARS-CoV-2 pandemic

Rev. Soc. Esp. Dolor. 2020; 27(6): 392-393 / DOI: 10.20986/resed.2020.3827/2020

Effectiveness and current recommendation of manual therapy on hip osteoarthritis. An overview

Rev. Soc. Esp. Dolor. 2020; 27(6): 375-391 / DOI: 10.20986/resed.2021.3835/2020

Transitional pain clinic

Rev. Soc. Esp. Dolor. 2020; 27(6): 369-374 / DOI: 10.20986/resed.2020.3840/2020

Study of pain in rehabilitation treatments

Rev. Soc. Esp. Dolor. 2020; 27(6): 361-368 / DOI: 10.20986/resed.2020.3809/2020

Impact of group psychological intervention on conventional radiofrequency tributary patients

Rev. Soc. Esp. Dolor. 2020; 27(6): 349-360 / DOI: 10.20986/resed.2020.3830/2020

Physical medicine, rehabilitation and pain

Rev. Soc. Esp. Dolor. 2020; 27(6): 333-335 / DOI: 10.20986/resed.2021.3888/2021

A 14-month physiotherapy follow up to a child with Sandifer syndrome

Rev. Soc. Esp. Dolor. 2020; 27(5): 329-331 / DOI: 10.20986/resed.2020.3816/2020

School of non-oncologic chronic pain patients and opioid treatment

Rev. Soc. Esp. Dolor. 2020; 27(5): 324-328 / DOI: 10.20986/resed.2020.3804/2020

Opioid misuse in patients with cancer pain: an integrative systematic review of the literature

Rev. Soc. Esp. Dolor. 2020; 27(5): 306-315 / DOI: 10.20986/resed.2020.3801/2020

Therapeutic failure of the lumbar medial branch block and its relation to obesity. Retrospective cohort study

Rev. Soc. Esp. Dolor. 2020; 27(5): 298-305 / DOI: 10.20986/resed.2020.3829/2020

Identification of signs and symptoms for the diagnosis of discogenic low back pain: mapping review

Rev. Soc. Esp. Dolor. 2020; 27(5): 292-297 / DOI: 10.20986/resed.2020.3803/2020

Efficacy of lidocaine perfusions in fibromyalgia: a prospective cohort study

Rev. Soc. Esp. Dolor. 2020; 27(5): 287-291 / DOI: 10.20986/resed.2020.3796/2020

Back to the future in the treatment of postoperative acute pain

Rev. Soc. Esp. Dolor. 2020; 27(5): 285-286 / DOI: 10.20986/resed.2020.3850/2020

Temporary peripheral nerve stimulation in cancer pain: opportunity options

Rev. Soc. Esp. Dolor. 2020; 27(5): 283-284 / DOI: 10.20986/resed.2020.3849/2020

Facings with discogenic pain

Rev. Soc. Esp. Dolor. 2020; 27(5): 281-282 / DOI: 10.20986/resed.2020.3848/2020

Pain: a "hotchpotch"

Rev. Soc. Esp. Dolor. 2020; 27(4): 278-280 / DOI: 10.20986/resed.2016.3507/2016

Splanchnic nerve block for the treatment of benign chronic abdominal pain. a case report and literature review

Rev. Soc. Esp. Dolor. 2020; 27(4): 273-277 / DOI: 10.20986/resed.2020.3818/2020

Clinical pathophysiology in patients with sickle cell disease: the transition from acute to chronic pain

Rev. Soc. Esp. Dolor. 2020; 27(4): 257-268 / DOI: 10.20986/resed.2020.3814/2020

Gender determinants in the approach to chronic pain

Rev. Soc. Esp. Dolor. 2020; 27(4): 252-256 / DOI: 10.20986/resed.2020.3802/2020

Incidence of postmastectomy pain syndrome. Retrospective analysis

Rev. Soc. Esp. Dolor. 2020; 27(4): 246-251 / DOI: 10.20986/resed.2020.3797/2020

Sociodemographic and clinical characterization in patients with chronic back pain, Cienfuegos 2019

Rev. Soc. Esp. Dolor. 2020; 27(4): 239-245 / DOI: 10.20986/resed.2020.3798/2020

Spinal cord stimulation. Analysis of the diagnostic indications

Rev. Soc. Esp. Dolor. 2020; 27(4): 234-238 / DOI: 10.20986/resed.2020.3777/2019

Updated version of the IASP definition of pain: one step forward or one step back

Rev. Soc. Esp. Dolor. 2020; 27(4): 232-233 / DOI: 10.20986/resed.2020.3839/2020

Metamizole as an immunomodulator in neuropathic pain

Rev. Soc. Esp. Dolor. 2020; 27(4): 230-231 / DOI: 10.20986/resed.2020.3838/2020

Suboccipital decompression as an alternative in the treatment of pain secundary to occipital neuralgia: a case series

Rev. Soc. Esp. Dolor. 2020; 27(3): 221-226 / DOI: 10.20986/resed.2020.3791/2020

Symptomatic treatment for migraña. Drugs used and related variables. Results of the european survey on work and migraine

Rev. Soc. Esp. Dolor. 2020; 27(3): 178-191 / DOI: 10.20986/resed.2020.3744/2019

Drug consumption used for musculoskeletal pain treatment in a cohort of blue-collar workers in Zaragoza (Spain)

Rev. Soc. Esp. Dolor. 2020; 27(3): 150-159 / DOI: 10.20986/resed.2020.3749/2019

The pandemic that surprised us and has altered the care of patients with pain

Rev. Soc. Esp. Dolor. 2020; 27(3): 148-149 / DOI: 10.20986/resed.2020.3820/2020

The Pain Units in the COVID-19 era

Rev. Soc. Esp. Dolor. 2020; 27(3): 143-145 / DOI: 10.20986/resed.2020.3823/2020

Erector spinalis plane block as a neuropathic pain management in post-burned pediatric patient

Rev. Soc. Esp. Dolor. 2020; 27(2): 127-132 / DOI: 10.20986/resed.2020.3776/2019

Management of breakthrough pain associated with the cure of skin ulcers

Rev. Soc. Esp. Dolor. 2020; 27(2): 113-126 / DOI: 10.20986/resed.2020.3755/2019

Ethical problems in the management of pain. Qualitative study through open reflection interview

Rev. Soc. Esp. Dolor. 2020; 27(2): 89-96 / DOI: 10.20986/resed.2020.3729/2019

Altruistic conduct: a behavioral strategy to decrease the perception of pain?

Rev. Soc. Esp. Dolor. 2020; 27(2): 76-77 / DOI: 10.20986/resed.2020.3806/2020

COVID-19 coronavirus and chronic pain: uncertainties

Rev. Soc. Esp. Dolor. 2020; 27(2): 72-73 / DOI: 10.20986/resed.2020.3808/2020

The ozone paradigm in pain treatment

Rev. Soc. Esp. Dolor. 2020; 27(2): 69-71 / DOI: 10.20986/resed.2020.3807/2020

Conventional radiofrequency for genicular nerves in treatment of knee osteoarthritis

Rev. Soc. Esp. Dolor. 2020; 27(1): 59-60 / DOI: 10.20986/resed.2016.3515/2016

Review of the impact of acupuncture treatment on the management of nonspecific low back pain

Rev. Soc. Esp. Dolor. 2020; 27(1): 53-58 / DOI: 10.20986/resed.2020.3762/2019

Effectiveness of the association of lacosamide in trigeminal neuralgia

Rev. Soc. Esp. Dolor. 2020; 27(1): 50-52 / DOI: 10.20986/resed.2019.3738/2019

Peripheral acting Mu opioid receptor antagonists in the treatment of the opioid-induced constipation: review

Rev. Soc. Esp. Dolor. 2020; 27(1): 37-49 / DOI: 10.20986/resed.2020.3717/2018

Effectiveness of patient-controlled analgesia in acute and chronic pain after cardiac surgery: a prospective study

Rev. Soc. Esp. Dolor. 2020; 27(1): 24-36 / DOI: 10.20986/resed.2020.3747/2019

Efficacy of pregabalin, gabapentin and duloxetine in neuropathic pain verified by the p-curve analysis

Rev. Soc. Esp. Dolor. 2020; 27(1): 16-23 / DOI: 10.20986/resed.2020.3727/2019

Spinal stimulation modulated automatically. Evidence of closed stimulation systems: towards the pain pacemaker

Rev. Soc. Esp. Dolor. 2020; 27(1): 5-6 / DOI: 10.20986/resed.2020.3793/2020

News in the treatment of back pain: are the future cell therapies?

Rev. Soc. Esp. Dolor. 2020; 27(1): 3-4 / DOI: 10.20986/resed.2020.3792/2020

Considerations for the use of evidence-based practice in the management of people with pain

Rev. Soc. Esp. Dolor. 2019; 26(6): 374-375 / DOI: 10.20986/resed.2019.3712/2018

Intratecal baclophene for the treatment of pain and spasticity in stiff man syndrome: a case report

Rev. Soc. Esp. Dolor. 2019; 26(6): 368-371 / DOI: 10.20986/resed.2019.3745/2019

Key factors governing spinal cord opioid bioavailability in the management of acute pain

Rev. Soc. Esp. Dolor. 2019; 26(6): 359-367 / DOI: 10.20986/resed.2019.3737/2019

Neurolytic procedures for pancreatic cáncer pain: a systematic review and a proposal for an algorithm treatment

Rev. Soc. Esp. Dolor. 2019; 26(6): 342-358 / DOI: 10.20986/resed.2019.3715/2018

Correlation between pain and radiological parameters in patients older than 60 years of age with distal radius fracture

Rev. Soc. Esp. Dolor. 2019; 26(6): 324-330 / DOI: 10.20986/resed.2019.3720/2018

Connexins in chronic pain. A new target?

Rev. Soc. Esp. Dolor. 2019; 26(6): 322-323 / DOI: 10.20986/resed.2019.3785/2019

Celiac axis block in cancer pain: medicine of opportunity

Rev. Soc. Esp. Dolor. 2019; 26(6): 317-319 / DOI: 10.20986/resed.2019.3787/2019

Pyoderma gangrenosum, undocumented complication of a spinal cord stimulation

Rev. Soc. Esp. Dolor. 2019; 26(5): 309-312 / DOI: 10.20986/resed.2019.3725/2019

New strategies for postoperative pain control in tonsillectomy surgery. Is all that glitters gold?

Rev. Soc. Esp. Dolor. 2019; 26(5): 270-275 / DOI: 10.20986/resed.2019.3742/2019

The use of new technologies in patients with chronic pain. A reality that cannot be denied

Rev. Soc. Esp. Dolor. 2019; 26(5): 259-260 / DOI: 10.20986/resed.2019.3766/2019

Epidural injections: caudal, interlaminar or transforaminal. More than a shot

Rev. Soc. Esp. Dolor. 2019; 26(5): 255-258 / DOI: 10.20986/resed.2019.3764/2019

New ACP guidelines for non-radicular low back pain

Rev. Soc. Esp. Dolor. 2019; 26(4): 254-254 / DOI: 10.20986/resed.2017.3590/2017

Painful diabetic foot ulcer amputation avoided thanks to topical sevoflurane

Rev. Soc. Esp. Dolor. 2019; 26(4): 253-253 / DOI: 10.20986/resed.2018.3683/2018

NMDA antagonism in the treatment of cluster headache

Rev. Soc. Esp. Dolor. 2019; 26(4): 247-250 / DOI: 10.20986/resed.2019.3710/2018

Orofacial pain in the dental clinic

Rev. Soc. Esp. Dolor. 2019; 26(4): 233-242 / DOI: 10.20986/resed.2019.3724/2019

Characterization of pain in patients with breast cancer attending the Oncology Unit of the San José Hospital

Rev. Soc. Esp. Dolor. 2019; 26(4): 221-226 / DOI: 10.20986/resed.2019.3692/2018

Comparative analysis of vital signs in acutely hospitalized patients according to the pain intensity

Rev. Soc. Esp. Dolor. 2019; 26(4): 215-220 / DOI: 10.20986/resed.2019.3707/2018

The new international classification of diseases (ICD-11) and chronic pain. Pragmatical implications

Rev. Soc. Esp. Dolor. 2019; 26(4): 209-210 / DOI: 10.20986/resed.2019.3752/2019

Manual therapy, a double-edged weapon in the management of chronic pain

Rev. Soc. Esp. Dolor. 2019; 26(3): 206-207 / DOI: 10.20986/resed.2018.3675/2018

Opioid tapering may improve outcomes for chronic pain patients

Rev. Soc. Esp. Dolor. 2019; 26(3): 204-205 / DOI: 10.20986/resed.2017.3615/2017

Body pain, ethics and empathy: Utopia in the time of the mediate?

Rev. Soc. Esp. Dolor. 2019; 26(3): 203-203 / DOI: 10.20986/resed.2017.3599/2017

Erector spinae plane block for multiple unilateral ribs fractures.

Rev. Soc. Esp. Dolor. 2019; 26(3): 199-202 / DOI: 10.20986/resed.2019.3687/2018

Pain in Parkinson's disease. A look at a little known aspect of this pathology

Rev. Soc. Esp. Dolor. 2019; 26(3): 184-198 / DOI: 10.20986/resed.2019.3733/2019

Information and communication technologies applied among medical professionals who perform pain treatment

Rev. Soc. Esp. Dolor. 2019; 26(3): 175-183 / DOI: 10.20986/resed.2019.3709/2018

Optimization of postoperative pain management based on a new technological tool. Pain map

Rev. Soc. Esp. Dolor. 2019; 26(3): 154-165 / DOI: 10.20986/resed.2019.3696/2018

Sublingual fentanyl for the treatment of breakthrough cancer pain during allergic reactions to chemotherapy infusion

Rev. Soc. Esp. Dolor. 2019; 26(3): 148-153 / DOI: 10.20986/resed.2018.3689/2018

Recent advances in the use of light in pain research. Implications in physiology and pharmacology

Rev. Soc. Esp. Dolor. 2019; 26(3): 146-147 / DOI: 10.20986/resed.2019.3743/2019

Evidence and foresight of ultrasound-guided blocks for the painful shoulder

Rev. Soc. Esp. Dolor. 2019; 26(3): 144-145 / DOI: 10.20986/resed.2019.3741/2019

Top 10 bioethical issues in pain

Rev. Soc. Esp. Dolor. 2019; 26(2): 130-130 / DOI: 10.20986/resed.2018.3694/2018

Pulsed radiofrequency treatment in the neuropathy of the pudendal nerve: report of a case

Rev. Soc. Esp. Dolor. 2019; 26(2): 128-129 / DOI: 10.20986/resed.2016.3517/2016

Does pregabalin is a safe drug? Heart failure associated with pregabalin

Rev. Soc. Esp. Dolor. 2019; 26(2): 124-125 / DOI: 10.20986/resed.2017.3537/2016

Motor block after caudal epidural infiltration: a case report

Rev. Soc. Esp. Dolor. 2019; 26(2): 120-123 / DOI: 10.20986/resed.2018.3669/2018

Myofascial pain syndrome as a cause of postoperative acute pain in hip surgery

Rev. Soc. Esp. Dolor. 2019; 26(2): 117-119 / DOI: 10.20986/resed.2019.3655/2018

Fast opioid detoxification

Rev. Soc. Esp. Dolor. 2019; 26(2): 95-102 / DOI: 10.20986/resed.2019.3681/2018

Dry needling and changes in muscular activity in subjects with myphastial trigger points: case series

Rev. Soc. Esp. Dolor. 2019; 26(2): 89-94 / DOI: 10.20986/resed.2018.3677/2018

Effectiveness of hand crossing to produce analgesia in patients with chronic pain of the upper limb

Rev. Soc. Esp. Dolor. 2019; 26(2): 81-88 / DOI: 10.20986/resed.2019.3674/2018

Epidural steroids in lumbar radicular pain: particulate vs. non-particulate. This is the question

Rev. Soc. Esp. Dolor. 2019; 26(2): 70-71 / DOI: 10.20986/resed.2019.3735/2019

Opioids and addiction in chronic pain: is it a problem?, how to address it?

Rev. Soc. Esp. Dolor. 2019; 26(2): 65-67 / DOI: 10.20986/resed.2019.3736/2019

New indication of capsaicin 8 % patch: painful diabetic peripheral neuropathy

Rev. Soc. Esp. Dolor. 2019; 26(1): 60-61 / DOI: 10.20986/resed.2017.3556/2016

Oxytocin and chronic pain in humans

Rev. Soc. Esp. Dolor. 2019; 26(1): 52-58 / DOI: 10.20986/resed.2018.3664/2018

Influence of psychosocial factors in the experience of musculoskeletal pain: a literatura review

Rev. Soc. Esp. Dolor. 2019; 26(1): 44-51 / DOI: 10.20986/resed.2018.3679/2018

Project adapta: adequacy of treatment in breakthrough cancer pain

Rev. Soc. Esp. Dolor. 2019; 26(1): 31-43 / DOI: 10.20986/resed.2018.3661/2018

Psychosocial factors in chronic cancer pain: a Delphi study

Rev. Soc. Esp. Dolor. 2019; 26(1): 21-30 / DOI: 10.20986/resed.2018.3658/2018

Micro RNAs: A new way for the management of neuropathic pain?

Rev. Soc. Esp. Dolor. 2019; 26(1): 2-3 / DOI: 10.20986/resed.2019.3730/2019

Academic University training program of the Spanish Pain Society

Rev. Soc. Esp. Dolor. 2018; 25(6): 368-368

ACNES as a cause of chronic abdominal pain

Rev. Soc. Esp. Dolor. 2018; 25(6): 360-361 / DOI: 10.20986/resed.2017.3530/2016

Dysphonia as side-effect dose-dependent during treatment with duloxetine

Rev. Soc. Esp. Dolor. 2018; 25(6): 359-359 / DOI: 10.20986/resed.2017.3528/2016

Evidence-based recommendations for the management of neuropathic pain (review of the literature)

Rev. Soc. Esp. Dolor. 2018; 25(6): 349-358 / DOI: 10.20986/resed.2018.3673/2018

Changes in intraocular pressure in patients with trigeminal neuralgia subject to radio frequency of the Gasserian ganglion

Rev. Soc. Esp. Dolor. 2018; 25(6): 342-348 / DOI: 10.20986/resed.2018.3657/2018

Opinaudit study: clinical uses in breakthrough pain, is scientific evidence being followed up?

Rev. Soc. Esp. Dolor. 2018; 25(6): 325-334 / DOI: 10.20986/resed.2018.3634/2017

Use of major opioids for control of pain in hospitalized patients

Rev. Soc. Esp. Dolor. 2018; 25(6): 318-324 / DOI: 10.20986/resed.2018.3629/2017

Proctalgia and pudendal nerve entrapment: an association to know

Rev. Soc. Esp. Dolor. 2018; 25(6): 311-317 / DOI: 10.20986/resed.2018.3623/2017

Consensus for the definition of post-mastectomy pain syndrome

Rev. Soc. Esp. Dolor. 2018; 25(5): 305-306 / DOI: 10.20986/resed.2016.3510/2016

Radiofrequency thermal and splanchnics nerves block

Rev. Soc. Esp. Dolor. 2018; 25(5): 303-304 / DOI: 10.20986/resed.2016.3509/2016

Implications of bioethics in the treatment of chronic pain: the change of paradigms

Rev. Soc. Esp. Dolor. 2018; 25(5): 291-300 / DOI: 10.20986/resed.2018.3666/2018

Farmacologic adyuvants with saving effect of opioids in the perioperative period

Rev. Soc. Esp. Dolor. 2018; 25(5): 278-290 / DOI: 10.20986/resed.2018.3663/2018

Experience in two hospitals about the observation of pain responses in hospitalized preterm infants

Rev. Soc. Esp. Dolor. 2018; 25(5): 271-277 / DOI: 10.20986/resed.2018.3633/2017

Platelet-rich plasma in treating peripheral neuropathic pain. Preliminary report

Rev. Soc. Esp. Dolor. 2018; 25(5): 263-270 / DOI: 10.20986/resed.2017.3625/2017

Pain in the elderly and in patients with cognitive deficit. A DELPHI study

Rev. Soc. Esp. Dolor. 2018; 25(5): 251-262 / DOI: 10.20986/resed.2017.3621/2017

Chrono study: prevalence of breakthrough pain among patients with non-cancer chronic pain in Andalusia, Spain

Rev Soc Esp Dolor 2018; 25(4): 214-221 / DOI: 10.20986/resed.2017.3626/2017

Expenditure, prescription and consumption of analgesic drugs before and during the economic crisis

Rev Soc Esp Dolor 2018; 25(3): 155-162 / DOI: 10.20986/resed.2017.3609/2017

Sex and pain: sexual satisfaction and sexual function in a sample of patients with chronic, non-pelvic pain

Rev Soc Esp Dolor 2018; 25(3): 145-154 / DOI: 10.20986/resed.2018.3600/2017

Bibliometric analysis of the Journal of the Spanish Pain Society: 2007-2016

Rev Soc Esp Dolor 2018; 25(3):170-177 / DOI: 10.20986/resed.2018.3627/2017

Painometer v2®: a mobile application certified for monitoring patients with pain

Rev Soc Esp Dolor 2018; 25(2):112-120 / DOI: 10.20986/resed.2017.3555/2016

Analgesic efficacy of topical sevoflurane on wounds

Rev Soc Esp Dolor 2018; 25(2): 106-111 / DOI: 10.20986/resed.2017.3617/2017

Potential uses of Mirtazapine in palliative care beyond its antidepressant effect

Rev Soc Esp Dolor 2018; 25(1): 37-44 / DOI: 10.20986/resed.2017.3575/2017

Epidural analgesia vs. surgical wound analgesia to control acute post-operative pain in open colon surgery

Rev Soc Esp Dolor 2017; 24(5): 234-240 / DOI: 10.20986/resed.2017.3559/2016

Chronic pain: relationship with prefrontal symptoms and perceived stress

Rev Soc Esp Dolor 2017; 24(4): 179-187 / DOI: 10.20986/resed.2017.3540/2016

The effectiveness of electrical spinal-cord stimulation in type i complex regional pain syndrome. A literature review

Rev Soc Esp Dolor 2017; 24(4): 169-178 / DOI: 10.20986/resed.2016.3501/2016

Paxiflas®: new FDT combination of tramadol/paracetamol for treating moderate to severe pain

Rev Soc Esp Dolor 2017; 24(2):59-67 / DOI: 10.20986/resed.2017.3565/2017

Prevalence of breakthrough pain associated with chronic low back pain in Andalusia (COLUMBUS study)

Rev Soc Esp Dolor 2017; 24(3):116-124 / DOI: 10.20986/resed.2017.3548/2016

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Fernández-Cuadros M, Pérez-Moro O, Albaladejo-Florin M, Álava S. Intra-articular ozone modulates inflammation, ameliorates pain and stiffness, improves function and has anabolic effect on knee osteoarthritis: a prospective quasiexperimental before-and-after study, 115 patients. Rev Soc Esp Dolor 2020; 27(2): 78-88 / DOI: 1020986/resed20203775/2019


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Recibido: 28/10/2019

Aceptado: 16/02/2020

Prepublicado: 16/03/2020

Publicado: 17/04/2020

Tiempo de revisión del artículo: 107 días

Tiempo de prepublicación: 140 días

Tiempo de edición del artículo: 172 días


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