Year 2021 / Volume 28 / Number 1


Inflammatory mediators: its connection with chronic pain and associated problems. Review

Rev. Soc. Esp. Dolor. 2021; 28(1): 37-46 / DOI: 10.20986/resed.2021.3841/2020

Lidia Crespo, Yaiza Taboada


Introduction: Pain is a complex interaction of systems, with a process that integrates sensory, cognitive and/or emotional information that comes from real or potential threats. It has been observed a connection in the chronic pain with other somatic and psychological symptoms, such as depression, anxiety, lack of sleep, fatigue and reduction of cognitive capacity. It has been demonstrated that proinflammatory cytokines and associated symptoms influence in the probability of suffering chronic pain. The objective is to analyze the levels of the inflammatory mediators in diseases with chronic pain and with related disorders, so that we can better understand long-term pain.
Material and methods: To make this dissertation, a review of the scientific literature was carried out by a systematized search in the Pubmed, CINHAL, Medline, Scopus and Web of Science databases, in January 2020. The inclusion criteria were: to be documents written in English or Spanish and published in the last 5 years. The exclusion criteria were: review studies, and articles repeated in other databases or that addressed other topics.
Results: 13 articles were selected after applying inclusion and exclusion criteria. All publications were observational studies. Proinflammatory cytokine values were compared in patients with chronic pain, taking into account insomnia, pain tolerance, catastrophism, gender and body mass index.
Conclusion: Chronic pain is conditioned by multiple factors, so its physiopathology must be known. In this way, the measurement of the C-reactive protein and the proinflammatory cytokines could mean an advance in the evaluation and monitoring of the patient with chronic pain.


Introducción: El dolor es una compleja interacción de sistemas, con un proceso que integra información sensorial, cognitiva y/o emocional proveniente de amenazas reales o potenciales. En el dolor crónico se ha observado una relación con otros síntomas somáticos y psicológicos como la depresión y la ansiedad, falta de sueño, fatiga y disminución de la capacidad cognitiva. Se ha demostrado que las citoquinas proinflamatorias y los síntomas asociados influyen en la probabilidad de padecer dolor crónico. El objetivo es analizar los niveles de los mediadores inflamatorios en patologías que cursan con dolor crónico y los trastornos relacionados para así comprender mejor el dolor de larga duración.
Material y métodos: Para la realización de este trabajo se realizó una revisión de la literatura científica mediante una búsqueda sistematizada en enero de 2020 en las bases de datos Pubmed, CINHAL, Medline, Scopus y Web of Sciencie. Se aplicaron como criterios de inclusión: ser documentos publicados en los últimos 5 años y estar escritos en inglés o castellano. Como criterios de exclusión: estudios de revisión, artículos repetidos en otras bases o que trataran sobre otro tema.
Resultados: 13 artículos fueron seleccionados tras aplicar los criterios de inclusión y exclusión. Todas las publicaciones son estudios observacionales. Se compararon los valores de citoquinas proinflamatorias en pacientes con dolor crónico, teniendo en cuenta el insomnio, la tolerancia al dolor, el catastrofismo, el género y el índice de masa corporal.
Conclusión: El dolor crónico está condicionado por múltiples factores, por lo que se debe conocer la fisiopatología del mismo. De esta manera, la medición de la proteína C reactiva y de citoquinas proinflamatorias podría suponer un avance en la evaluación y seguimiento del paciente con dolor crónico.

Complete Article


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Tablas y Figuras

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Instrucciones para citar

Crespo L, Taboada Y. Inflammatory mediators: its connection with chronic pain and associated problems. Review. Rev Soc Esp Dolor 2021; 28(1): 37-46 / DOI: 1020986/resed20213841/2020

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Recibido: 19/08/2020

Aceptado: 02/12/2020

Prepublicado: 12/01/2021

Publicado: 17/03/2021

Tiempo de revisión del artículo: 89 días

Tiempo de prepublicación: 146 días

Tiempo de edición del artículo: 210 días


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ISSN: 1134-8046   e-ISSN: 2254-6189

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